陈德坤
一、个人基本信息
陈德坤,男,陕西渭南人,博士研究生学历,博士学位,教授,博士研究生指导教师。西北农林科技大学动物医学院教授,陕西省免疫学会常务理事,陕西省奶山羊现代农业产业技术体系岗位专家,陕西省羊产业技术创新联盟专家委员会委员,全国动物防疫专家委员会委员,动物医学进展杂志编委。发表SCI论文30余篇,中文核心期刊及以上论文130余篇。获批国家发明专利9件。
二、教育及研究经历
教育经历
1982年9月-1986年7月四川大学生物系动物学专业,获理学学士学位
1992年9月-1995年7月 西北农业大学兽医系兽医微生物与免疫学专业,获农学学士学位
2001年9月-2004年7月 西北农林科技大学动物科技学院临床兽医学专业,获农学博士学位
研究经历
1986.7---1993.12 西北农学院兽医系,助教。
1994.1---1998.12 西北农业大学兽医系,讲师
1999.1---2004.12 西北农林科技大学动物医学院,副教授
2004.12---迄今 西北农林科技大学动物医学院,教授
2007年1月-2008年1月 澳大利亚昆士兰大学,访问学者
三、研究方向及开设课程
研究领域为动物重大疫病免疫防控。研究方向主要为山羊重大疫病免疫防治,以及大熊猫和小熊猫的重大传染病防治。研究内容主要包括流行病调查与病原分离鉴定、病原相关分子及免疫分子的单克隆抗体研制、检测试剂盒与疫苗开发、机体抗感染免疫机制研究等。
为本科生开设《兽医免疫学》课程,为全校研究生开设《免疫学原理与技术》公共课,为预防兽医学专业开设《细胞与分子免疫学》、《兽医生物制品研发的理论与实践》课程。
四、代表性学术成果(含论著、论文)
Cheng Hongyu, Li Weijuan, Li Xingming, Fan Qinlei, Tang Xidian, Liu Mingjie, Ma Wentao*, Chen Dekun*, Pathogenicity of blood orf virus isolates in the development of dairy goat contagious pustular dermatitis. Veterinary Microbiology, 2018(219):178-82.(兽医学Top期刊,影响因子="3.03)
Ma Wentao#*, Gu Kui#, Yang Rui, Qi Yuxu, Liu Mingjie, Chen Dekun*, Interleukin-17 mediates lung injury by promoting neutrophil accumulation during the development of contagious caprine pleuropneumonia. Veterinary Microbiology, 2020(243):108651.(兽医学Top期刊,影响因子="3.03" )
Tong Juanzhen#, Ma Wentao#, Yang Rui, Wang Tianxing, Chen Xi, Zhang Xinyue, Tang Xidian, Wen Ying, Chang Jianjun*, Chen Dekun*, Dysbiosis of the gut microbiota maybe exacerbate orf pathology by promoting inflammatory immune responses, Veterinary Microbiology, 2020(251):108884. (兽医学Top期刊,影响因子="3.03" )
Tang Xidian, Jing Tian, Chen Xi, Wang Tianxing, Xie Yanfei, Chen Fengqiang, Wen Ying, Chang Jianjun, Chen Dekun*, Ma Wentao*, Interleukin-17 mediates inflammatory tissue injury during orf development in goats, Veterinary Microbiology 258 (2021) 109105. (兽医学Top期刊,影响因子="3.03" )
Pang Ming, Guan Xiong, Zuo Chenxiang, Liu Mingjie, Saad Rehman, Fan Qinlei, Lu Ping, Chen Dekun, Ma Wentao*. Development of a Monoclonal Antibody to Detect αs1-casein in the Milk of Healthy and Mastitis-Affected Goats, Kafkas Universitesi Veteriner Fakultesi Dergisi, 2019(26):71-74. (本科生发表,影响因子="0.489)
Ni Silu, Gao Fei, Zuo Chenxiang, Tang Xidian, Liu Mingjie, Chang Jianjun, Wang Yong, Chen Dekun Chen, Ma Wentao*, Neutrophils: A Critical Participator in Common Diseases of Ruminants, Kafkas Universitesi Veteriner Fakultesi Dergisi, 2020,26(5): 719-727. (本科生发表,影响因子="0.489)
Ma Wentao#, Liu Qi#, Ning Mengxia, Qi Yuxu, Saad Rehman, Chen Denkun*, Development and applications of a monoclonal antibody against caprine interferon-gamma, BMC Biotechnology, 2019(19). (影响因子="2.312)
Gao Yang, Sang Fengfeng, Meng Delan, Wang Yi, Ma Wentao*, Chen Dekun*, Preparation of a novel monoclonal antibody against caprine interleukin-17A and its applications in immunofluorescence and immunohistochemistry assays, BMC Biotechnology, 2019 (19):47. (影响因子="2.312)
Ma Wentao, Wang Yi, Gao Fei, Ning Mengxia, Liu Ahua, Li Yanyan, Gao Yang, Lu Ping, Chen Dekun*, Development of a Monoclonal Antibody against Bovine α-casein to Evaluate Functional Status of Mammary Epithelial Cells During Mastitis, Kafkas Universitesi Veteriner Fakultesi Dergisi, 2019(25):445-450. (影响因子="0.489)
Yao Xiaoting, Pang Ming, Wang Tianxing, Chen Xi, Tang Xidian, Chang Jianjun, Chen Dekun*, Ma Wentao*. Genomic Features and Evolution of the Parapoxvirus during the Past Two Decades, Pathogens, 2020, 9(11), 888. (影响因子="3.02)
Chang Jianjun#*, Yao Xiaoting#, Zuo Chenxiang, Qi Yuxu, Chen Dekun*, Ma Wentao*, The gut bacterial diversity of sheep associated with different breeds in Qinghai province, BMC Veterinary Research, 2020,16(1):254. (影响因子= 1.835)
Zhannur Niyazbekova, Yao Xiaoting, Liu MingJie, Bold Nomin, Tong Juanzhen, Chang Jianjun, Wen Ying, Li Li, Wang Yong, Chen Dekun*, Ma Wentao*. Compositional and Functional Comparisons of the Microbiota in the Colostrum and Mature Milk of Dairy Goats, Animals, 2020, 10(11): 1955. (影响因子="2.32)
Hong-Yu Cheng, Meng-Xia Ning, De-Kun Chen*, Wen-Tao Ma*, Interactions between the gut microbiota and the host innate immune response against pathogens, Frontiers in Immunology, 2019(10):607. (影响因子="5.085)
Mingjie Liu, Saad Rehman, Xidian Tang, Kui Gu, Qinlei Fan, Dekun Chen* and Wentao Ma*, Methodologies for Improving HDR Efficiency, Frontiers in Genetics. 2019; 9:691. (影响因子="3.258)
Hongyu Cheng, Xiong Guan, Dekun Chen* and Wentao Ma*, The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story, Microorganisms, 2019(7). Doi: 10.3390/microorganisms7120583. (影响因子="4.152).
Ma Wentao*, Yao Xiaoting, Peng Qun, Chen Dekun*. The protective and pathogenic roles of IL-17 in viral infections: friend or foe? Open Biology, 2019. (影响因子="4.931)
Tang Xidian, Gao Fei, Liu Mingjie, Fan Qinlei, Chen Dekun*, Ma Wentao*, Methods for Enhancing Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Homology-Directed Repair Efficiency, Frontiers in Genetics, 2019(10):551. Doi: 10.3389/fgene.2019.00551. (影响因子="3.258)
Ma Wentao*, Gao Fei, Gu Kui, Chen Dekun*, The Role of Monocytes and Macrophages in Autoimmune Diseases: A Comprehensive Review, Frontiers in Immunology, 2019 (10):1140. (影响因子="5.085)
Ma Wentao*, Chen Dekun*, Immunological Abnormalities in Patients with Primary Biliary Cholangitis, Clinical Science, 2019(133):741-760. (影响因子="5.223)
获得授权发明专利:
一种奶山羊隐性乳房炎快速诊断试剂。 ZL 200910024340.7
一种用于羊口疮病毒增殖的永久细胞系制备方法。ZL 201110452708.7
奶山羊乳房炎病原菌多重PCR检测试剂盒的制备方法。ZL 201210394431.1
一种山羊伪结核杆菌抗体的ELISA检测试剂盒的制备方法。ZL 201510458766.9
预防山羊葡萄球菌乳房炎的亚单位疫苗的制备方法及应用。ZL 201210116696.5
预防山羊葡萄球菌乳房炎的基因工程疫苗制备方法及应用。ZL 201210394438.3
羊口疮抗体检测试剂盒的制备方法。ZL 201210183987.6
一种羊口疮病毒的快速分离方法。ZL 2015100773292
羊口疮病毒低含量样品的病毒分离方法。ZL 2015101527026
五、荣誉及奖项
“奶山羊良种繁育与产业化关键技术研究与示范”获得2014年杨凌示范区科学技术奖一等奖、2015年陕西省科学技术奖二等奖。
六、联系方式
联系电话:029-87092134
电子邮箱:chendekun163@163.com