王高学
1、基本信息
王高学，男，汉族，1965年9月生，陕西省富平人，西北农林科技大学水产科学系教授，博士，博士生导师。主要兼职：教育部水产类专业教学指导委员会委员；中国水产学会鱼病专业委员会委员；中国水产学会渔药专业委员会委员。
2. 研究方向
主要从事水产动物病害防治、基因工程疫苗和渔药创制领域的研究，具体为：
（1）天然产物与生物源渔药创制
以天然植物、微生物为研究对象，筛选、分离获得杀灭病原菌、蓝藻、鱼类寄生虫、增强动物免疫及抗病力的天然产物，进一步创制无公害生物源渔药；结合发酵工程、化工合成，研究高活性分子构效关系，合成创制水产专用原料药。
（2）纳米载药研究与应用
应用无机或有机纳米材料作为药物载体，并结合化学修饰，研究纳米材料跨膜、靶向作用、缓释、透表皮黏膜作用、基因转染等机制，揭示纳米粒子的粒径、电荷、亲水亲脂性及靶向因子对纳米药物的吸收、分布、代谢、消除和毒性的影响规律。进行的纳米载药研究，突破了渔用疫苗大规模非注射免疫技术和水产无特定病原携带种苗（SPF）技术的瓶颈，极大推进渔用疫苗大规模商业化应用的进程。
（3）水生动物肠道有益微生物及EM研究
重点研究主要养殖水产动物肠道有益微生物菌群；研究有益菌株与病原菌之间的拮抗关系；筛选抗病、促生长的有益微生物，开发水产动物专用微生物制剂、发酵饲料菌种和水环境改良剂。
3. 承担课程
承担本科生《水产动物病害学》，研究生《高级水生生物学及实验技术》等课程的教学任务。
4. 学术成果
近年来，主持国家自然科学基金5项，其中联合基金重点支持项目1项；主持陕西省科技攻关、陕西省科技统筹创新工程计划项目及横向课题等10余项；参加十二五国家“863”项目2项、国家科技支撑计划项目2项、星火计划1项。共发表研究论文170余篇，第一作者或通讯作者发表SCI论文130多篇；出版专著4本；申请国家发明专利24项。近3年的主要代表作为:
1. Zhu S, Huang AG, Luo F, Li J, Li J, Zhu L, Zhao L, Zhu B, Ling F, Wang GX*. Application of virus targeting nanocarrier drug delivery system in virus-induced central nervous system disease treatment. ACS Applied Materials & Interfaces, 2019, 11: 19006-19016. (IF2018="8.456)
2. Zhu S, Li J, Huang AG, Huang JQ, Huang YQ, Wang GX*. Anti-betanodavirus activity of isoprinosine and improved efficacy using carbon nanotubes based drug delivery system. Aquaculture, 2019, 512. (IF2018="3.022)
3. Huang AG, Tu X, Qi XZ, Ling F, Zhu B*, Wang GX*. Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii. Aquaculture, 2019, 504: 239-247. (IF2018=3.022)
4. Huang AG, Tan XP, Qu SY, Wang GX*, Zhu B*. Evaluation on the antiviral activity of genipin against white spot syndrome virus in crayfish. Fish & Shellfish Immunology, 93: 380-386. (IF2018=3.298)
5. Hu Y, Liu L, Li BY, Shen YF, Wang GX*, Zhu B*. Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus. European Journal of Medicinal Chemistry, 163: 183-194. (IF2018=4.833)
6. Hu Y, Chen WC, Shen YF, Zhu B*, Wang GX*. Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo. Fish & Shellfish Immunology, 92: 736-745. (IF2018="3.298)
7. Hu Y, Shen YF, Tu X, Wu XH, Wang GX*, Ling F*. Isolation of anti-Saprolegnia lignans from Magnolia officinalis and SAR evaluation of honokiol/magnolol analogs. Bioorganic & Medicinal Chemistry Letters, 2019, 29: 389-395. (IF2018="2.448)
8. Hu Y, Chen WC, Shen YF, Zhu B*, Wang GX*. Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietic necrosis virus. Bioorganic & Medicinal Chemistry Letters, 2019, 29: 1749-1755. (IF2018="2.448)
9. Hu Y, Shen YF, Li BY, Wang GX*, Zhu B*. Evaluation on the antiviral activity of ribavirin against infectious hematopoietic necrosis virus in epithelioma papulosum cyprini cells. Virus Research, 2019, 263: 73-79. (IF2018="2.736)
10. Shen YF, Hu Y, Zhu B*, Wang GX*. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus Research, 2019, 268: 38-44. (IF2018="2.736)
11. Shen YF, Hu Y, Zhang Z, Liu L, Chen C, Tu X, Wang GX*, Zhu B*. Saikosaponin D efficiently inhibits SVCV infection in vitro and in vivo. Aquaculture, 2019, 504: 281-290. (IF2018=3.022)
12. Luo F, Zhu S, Hu Y, Yang KC, He MS, Zhu B, Wang GX*, Ling F*. Biocompatibility assessment of Fe3O4 nanoparticles using Saccharomyces cerevisiae as a model organism. Comparative Biochemistry and Physiology-Part C, 2019, 227: 108645. (IF2018=2.697)
13. Li BY, Hu Y, Li J, Shi K, Shen YF, Zhu B*, Wang GX*. Ursolic acid from Prunella vulgaris L. efficiently inhibits IHNV infection in vitro and in vivo. Virus Research, 2019, 273. (IF2018="2.736)
14. Zhu B*, Zhang C, Yang B, Guo ZR, Zheng YY, Gong YM, Wang GX*. Preliminary screening and immunogenicity analysis of antigenic epitopes of spring viremia of carp virus. Fish & Shellfish Immunology, 2019, 94: 833-841. (IF2018="3.298)
15. Li J, Wu ZB, Zhang Z, Zha JW, Qu SY, Qi XZ, Wang GX*, Ling F*. Effects of potential probiotic Bacillus velezensis K2 on growth, immunity and resistance to Vibrio harveyi infection of hybrid grouper (Epinephelus lanceolatus male x E. fuscoguttatus female). Fish & Shellfish Immunology, 2019, 93: 1047-1055. (IF2018="3.298)
16. Zhao Z, Zhang C, Jia YJ, Qiu DK, Lin Q, Li NQ, Huang ZB, Fu XZ, Wang GX*, Zhu B*. Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine. Fish & Shellfish Immunology, 2019, 92: 133-140. (IF2018="3.298)
17. Zhu S, Luo F, Li J, Zhu B*, Wang GX*. Biocompatibility assessment of single-walled carbon nanotubes using Saccharomyces cerevisiae as a model organism. Journal of Nanobiotechnology, 2018, 16: 44. (IF2018="5.345)
18. Shen YF, Liu L, Chen WC, Hu Y, Zhu B, Wang GX*. Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus. Aquaculture, 2018, 483: 252-262. (IF2018="3.022)
19. Shen YF, Liu L, Feng CZ, Hu Y, Chen C, Wang GX*, Zhu Bin*. Synthesis and antiviral activity of a new coumarin derivative against spring viraemia of carp virus. Fish & Shellfish Immunology, 2018, 81: 57-66. (IF2018="3.298)
20. Tu X, Huang AG, Hu Y, Ling F*, Wang GX*. Arctigenin: an emerging candidate against infections of Gyrodactylus. Aquaculture, 2018, 495: 983-991. (IF2018="3.022)
21. Hu Y, Shen YF, Wu XH, Tu X, Wang GX*. Synthesis and biological evaluation of coumarin derivatives containing imidazole skeleton as potential antibacterial agents. European Journal of Medicinal Chemistry, 2018, 143: 958-969. (IF2018="4.833)
22. Chen WC, Hu Y, Liu L, Shen YF, Wang GX*, Zhu B*. Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus. Fish & Shellfish Immunology, 2018, 82: 17-26. (IF2018="3.298)
23. Chen WC, Liu L, Shen YF, Hu Y, Ling F, Wang GX*, Zhu B*. A new coumarin derivative plays a role in rhabdoviral clearance by interfering glycoprotein function during the early stage of viral infection. Cellular Signalling, 2018, 51: 199-210. (IF2018="3.388)
24. Zhang C, Li LH, Wang J, Zhao Z, Li J, Tu X, Huang AG, Wang GX*, Zhu B*. Enhanced protective immunity against spring viremia of carp virus infection can be induced by recombinant subunit vaccine conjugated to single-walled carbon nanotubes. Vaccine, 2018, 36: 6334-6344. (IF2018="3.269)
25. Zhang C, Zhao Z, Liu GY, Li J, Wang GX*, Zhu B*. Immune response and protective effect against spring viremia of carp virus induced by intramuscular vaccination with a SWCNTs-DNA vaccine encoding matrix protein. Fish & Shellfish Immunology, 2018, 79: 256-264. (IF2018="3.298)
26. Chen XH, Hao K, Yu XB, Huang AG, Zhu Bin, Wang GX*, Ling F, Magnolol protects Ctenopharyngodon idella kidney cells from apoptosis induced by grass carp reovirus. Fish & Shellfish Immunology, 2018, 74: 426-435. (IF2018="3.298)
27. Chen C, Shen YF, Hu Y, Liu L, Chen WC, Wang GX*, Zhu B*. Highly efficient inhibition of spring viraemia of carp virus replication in vitro mediated by bavachin, a major constituent of psoralea corlifonia Lynn. Virus Research, 2018, 255: 24-35. (IF2018="2.736)
28. Hao K, Chen XH, Qi XZ, Zhu B, Wang GX*, Ling F. Display of GCRV vp7 protein on the surface of Escherichia coli and its immunoprotective effects in grass carp (Ctenopharyngodon idella). Fish & Shellfish Immunology, 2018, 72: 199-209. (IF2018="3.298)
29. Shan LP, Chen XH, Ling F, Zhu B*, Wang GX*. Targeting heat shock protein 70 as an antiviral strategy against grass carp reovirus infection. Virus Research, 2018, 247: 1-9. (IF2018="2.736)
30. Yi YL, Zhang ZH, Zhao F, Li H, Yu LJ, Zha JW, Wang GX*. Probiotic potential of Bacillus velezensis JW: Antimicrobial activity against fish pathogenic bacteria and immune enhancement effects on Carassius auratus. Fish & Shellfish Immunology, 2018 78: 322-330. (IF2018="3.298)
31. Yu XB, Hao K, Li J, Chen XH, Wang GX*, Ling F. Effects of moroxydine hydrochloride and ribavirin on the cellular growth and immune responses by inhibition of GCRV proliferation. Research in Veterinary Science, 2018, 117: 37-44. (IF2018="1.751)
32. Wu ZB, Ling F*, Song CG, Chen WC, Wang GX*. Effects of oral administration of whole plants of Artemisia annua on Ichthyophthirius multifiliis and Aeromonas hydrophila after parasitism by I. multifiliis. Parasitology Research, 2017, 116: 91-97. (IF2018=" 2.067)
33. Zhu S, Luo F, Chen WC, Zhu B, Wang GX*. Toxicity evaluation of graphene oxide on cysts and three larval stages of Artemia salina. Science of the Total Environment, 2017, 595: 101-109. (IF2018=" 5.589)
34. Chen XH, Hu Y, Shan LP, Yu XB, Hao K, Wang GX*. Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells. Fish & Shellfish Immunology, 2017, 63: 245-254. (IF2018="3.298)
35. Hao K, Chen XH, Qi XZ, Yu XB, Du EQ, Ling F, Zhu B*, Wang GX*. Protective immunity of grass carp induced by DNA vaccine encoding capsid protein gene (vp7) of grass carp reovirus using bacterial ghost as delivery vehicles. Fish & Shellfish Immunology, 2017, 64: 414-425. (IF2018="3.298)
36. Zhu S, Luo F, Zhu B*, Wang GX*. Toxicological effects of graphene oxide on Saccharomyces cerevisiae. Toxicology Research, 2017, 6: 535-543. (IF2018="1.593)
37. Hu Y, Liu L, Liu GL, Tu X, Wang GX*, Ling F*. Synthesis and anthelmintic activity of arctigenin derivatives against Dactylogyrus intermedius in goldfish. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 3310-3316. (IF2018="2.448)
38. Liu L, Tu X, Shen YF, Chen WC, Zhu B*, Wang GX*. The replication of spring viraemia of carp virus can be regulated by reactive oxygen species and NF-κB pathway. Fish & Shellfish Immunology, 2017, 67: 211-217. (IF2018="3.298)
39. Liu L, Hu Y, Shen YF, Wang GX*, Zhu B*. Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells. Antiviral Research, 2017, 144: 173-185. (IF2018=" 4.13)
40. Zhu S, Luo F, Zhu B*, Wang GX*. Mitochondrial impairment and oxidative stress mediated apoptosis induced by α-Fe2O3 nanoparticles in Saccharomyces cerevisiae. Toxicology Research, 2017, 6: 719-728. (IF2018="1.593)
41. Zhu S, Luo F, Tu X, Chen WC, Zhu B, Wang GX*. Developmental toxicity of oxidized multi-walled carbon nanotubes on Artemia salina cysts and larvae: Uptake, accumulation, excretion and toxic responses. Environmental Pollution, 2017, 229: 679-687. (IF2018=" 5.714)
42. Zhu S, Xue MY, Luo F, Chen WC, Zhu B, Wang GX*. Developmental toxicity of Fe3O4 nanoparticles on cysts and three larval stages of Artemia salina. Environmental Pollution, 2017, 230: 683-691. (IF2018=" 5.714)
43. Hao K, Wu ZQ, Li DL, Yu XB, Wang GX*, Ling F*. Effects of dietary administration of shewanella xiamenensis A-1, aeromonas veronii A-7, and bacillus subtilis, single or combined, on the grass carp (ctenopharyngodon idella) intestinal microbiota. Probiotics and Antimicrobial Proteins, 2017, 9: 386-396. (IF2018=" 2.962)
44. Qi XZ, Xue MY, Yang SB, Zha JW, Wang GX*, Ling F*. Ammonia exposure alters the expression of immune-related and antioxidant enzymes-related genes and the gut microbial community of crucian carp (Carassius auratus). Fish & Shellfish Immunology, 2017, 70: 485. (IF2018="3.298)
45. Zhang C, Zhao Z, Zha JW, Wang GX*, Zhu B*. Single-walled carbon nanotubes as a delivery vehicles enhance the immunoprotective effect of a DNA vaccine against spring viremia of carp virus in common carp. Fish & Shellfish Immunology, 2017, 71: 191-201. (IF2018="3.298)
5. 联系方式
通讯地址：陕西杨凌西农路22号西北农林科技大学动物科技学院水产系
邮编：712100
联系电话：029-87092102(办）
Email: wanggaoxue@126.com