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朱斌

发布日期:2021-07-07   阅读次数:

       1.基本信息  

  朱斌,男,1985年12月生,湖北宜昌人,博士,副教授、博士生导师。2015年7月入选西北农林科技大学“青年英才计划”留校任教。现为中国水产学会鱼病专业委员会会员。

  2.教育经历

  2012.9-2015.6,西北农林科技大学水生生物学专业获博士学位;

  2009.9-2012.6,西北农林科技大学水生生物学专业获硕士学位;

  2005.9-2009.6,西北农林科技大学水产养殖学专业获学士学位。

  3.工作经历

  2015.7至今,西北农林科技大学动物科技学院任教。

  4.研究方向

  主要从事水产动物病害防控研究,具体研究内容包括:(1)水产纳米载药系统的开发应用;(2)水产疫苗的分子设计和开发应用;(3)水产疫苗免疫分子机制研究。

  5.开设课程

  承担本科生《水产动物免疫学》、《鱼类药理学》、《水产动物病害学》和研究生《水生动植物疾病诊治及防控》等课程教学任务。

  6.学术成果

  主要围绕水产动物新型疫苗的创制及其分子免疫作用机制开展研究,现已获批主持国家和省部级等科研项目10余项。目前发表SCI论文50余篇,累计影响因子超过200。以第一作者或通讯作者在《Nanotoxicology》、《Journal of Nanobiotechnology》、《Antiviral Research》、《Vaccine》、《Cellular Signalling》、《Fish & Shellfish Immunology》和《Science of The Total Environment》等期刊发表SCI论文37篇,总影响因子超过130,其中包括中科院大类1区论文13篇、2区论文13篇,TOP期刊论文26篇。获批国家发明专利2项。

  6.1主持科研项目

  (1)陕西省自然科学基础研究计划-面上项目(2019JM-035),碳纳米管载鲤春病毒血症病毒DNA疫苗系统靶向免疫作用研究,2019.1-2020.12。

  (2)广东省水生经济动物良种繁育重点实验室开放基金,碳纳米管载鳜DNA疫苗系统免疫效果研究,2018.06-2019.12。

  (3)西北农林科技大学青年英才培育计划“卓越新星”资助(2452018029):水产动物纳米靶向抗病研究,2018.01-2020.12。

  (4)西北农林科技大学动物科技学院“博领青年学者”项目资助,2018.01-2019.12。

  (5)陕西省博士后科研配套资助项目:2017.06-2019.06。

  (6)中央高校基本科研业务费(2452017078):碳纳米管载鲤春病毒血症病毒疫苗系统靶向免疫作用研究,2017.01-2020.01。

  (7)农业部渔用药物创制重点实验室开放课题(201602):碳纳米管载鳜ISKNV疫苗系统研究,2017.01-2018.12。

  (8)国家自然科学基金-青年基金(31602204):碳纳米管载草鱼呼肠孤病毒DNA疫苗系统靶向免疫机制研究,2017.01-2019.12。

  (9)陕西省自然科学基础研究计划-青年人才项目(2016JQ3016):靶向甘露糖受体的草鱼出血病碳纳米管载体疫苗系统基础研究,2016.01-2017.12。

  (10)陕西省博士后科学基金二等资助(2016BSHEDZZ114):碳纳米管载嗜水气单胞菌疫苗系统靶向免疫作用机制研究,2016.03-2017.12。

  (11)中国博士后科学基金特别资助(2016T90956):碳纳米管载药系统靶向抗病毒和靶向免疫作用机制研究,2016.03-2017.12。

  (12)西北农林科技大学优博论文获得者留校基金(A213021620):2016.01- 2018.12。

  (13)中国博士后科学基金面上资助金一等资助(2015M580888):碳纳米管载药系统靶向抗草鱼呼肠孤病毒研究,2015.09-2017.07。

  (14)西北农林科技大学“青年英才计划”(Z111021510):碳纳米管载药靶向抗草鱼呼肠孤病毒研究,2015.09-2020.09。

  6.2代表性学术论文(*通讯作者)

  (1)Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of a new arctigenin derivative against IHNV in vitro and in vivo. Fish & Shellfish Immunology. 2019. (Accepted) (IF="3.298,Top期刊,中科院农林科学1区)

  (2)Zhao Zhao, Zhang Chen, Jia Yi-Jun, Qiu De-Kui, Lin Qiang, Li Ning-Qiu, Huang Zhi-Bin, Fu Xiao-Zhe, Wang Gao-Xue*, Zhu Bin*. Immersion vaccination of Mandarin fish Siniperca chuatsi against infectious spleen and kidney necrosis virus with a SWCNTs-based subunit vaccine. Fish & Shellfish Immunology. 2019, 92:133-140. (IF="3.298,Top期刊,中科院农林科学1区)

  (3)Shen Yu-Feng, Hu Yang, Zhu Bin*, Wang Gao-Xue*. Antiviral activity of anisomycin against spring viraemia of carp virus in epithelioma papulosum cyprini cells and zebrafish. Virus Research. 2019, 268:38-44. (IF="2.736,中科院医学3区)

  (4)Hu Yang, Chen Wei-Chao, Shen Yu-Feng, Zhu Bin*, Wang Gao-Xue*. Synthesis and antiviral activity of coumarin derivatives against infectious hematopoietic necrosis virus. Bioorganic & Medicinal Chemistry Letters. 2019, 29(14):1749-1755. (IF="2.448,中科院医学3区)

  (5)Hu Yang, Liu Lei, Li Bo-Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus. European Journal of Medicinal Chemistry. 2019, 163:183-194. (IF="4.833,Top期刊,中科院医学2区)

  (6)Zhang Chen, Zhao Zhao, Li Jian, Song Kai-Ge, Hao Kai, Wang Jin, Wang Gao-Xue, Zhu Bin*. Bacterial ghost as delivery vehicles loaded with DNA vaccine induce significant and specific immune responses in common carp against spring viremia of carp virus. Aquaculture. 2019, 504:361-368. (IF="3.022,Top期刊,中科院农林科学2区)

  (7)Huang Ai-Guo, Tu Xiao, Qi, Xiao-Zhou, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Gardenia jasminoides Ellis inhibit white spot syndrome virus replication in red swamp crayfish Procambarus clarkii. Aquaculture. 2019, 504:239-247. (IF="3.022,Top期刊,中科院农林科学2区)

  (8)Shen Yu-Feng, Hu Yang, Zhang Zhao, Liu Lei, Chen Cheng, Tu Xiao, Wang Gao-Xue*, Zhu Bin*. Saikosaponin D efficiently inhibits SVCV infection in vitro and in vivo. Aquaculture. 2019, 504:281-290. (IF="3.022,Top期刊,中科院农林科学2区)

  (9)Hu Yang, Shen Yu-Feng, Li Bo-Yang, Wang Gao-Xue*, Zhu Bin*. Evaluation on the antiviral activity of ribavirin against infectious hematopoietic necrosis virus in epithelioma papulosum cyprini cells. Virus Research. 2019, 263:73-79. (IF="2.736,中科院医学3区)

  (10)Zhu Song, Luo Fei, Li Jian, Zhu Bin*, Wang Gao-Xue*. Biocompatibility assessment of single-walled carbon nanotubes using Saccharomyces cerevisiae as a model organism. Journal of Nanobiotechnology. 2018, 16(1):44. (IF="5.345,Top期刊,中科院工程技术1区)

  11)Zhang Chen, Li Lin-Han, Wang Jin, Zhao Zhao, Li Jian, Tu Xiao, Huang Ai-Guo, Wang Gao-Xue*, Zhu Bin*. Enhanced protective immunity against spring viremia of carp virus infection can be induced by recombinant subunit vaccine conjugated to single-walled carbon nanotubes. Vaccine. 2018, 36(42):6334-6344. (IF="3.269,Top期刊,中科院医学2区)

  12)Chen Wei-Chao, Liu Lei, Shen Yu-Feng, Hu Yang, Ling Fei, Wang Gao-Xue*, Zhu Bin*. A new coumarin derivative plays a role in rhabdoviral clearance by interfering glycoprotein function during the early stage of viral infection. Cellular Signalling. 2018, 51:199-210. (IF="3.388,中科院生物2区)

  13)Chen Wei-Chao, Hu Yang, Liu Lei, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 82:17-26. (IF="3.298,Top期刊,中科院农林科学1区)

  14)Shen Yu-Feng, Liu Lei, Feng Cheng-Zhang, Hu Yang, Chen Cheng, Wang Gao-Xue*, Zhu Bin*. Synthesis and antiviral activity of a new coumarin derivative against spring viraemia of carp virus. Fish & Shellfish Immunology. 2018, 81:57-66. (IF="3.298,Top期刊,中科院农林科学1区)

  15)Zhang Chen, Zhao Zhao, Liu Gao-Yang, Li Jian, Wang Gao-Xue*, Zhu Bin*. Immune response and protective effect against spring viremia of carp virus induced by intramuscular vaccination with a SWCNTs-DNA vaccine encoding matrix protein. Fish & Shellfish Immunology. 2018, 79:256-264. (IF="3.298,Top期刊,中科院农林科学1区)

  (16)Shan Li-Peng, Chen Xiao-Hui, Ling Fei, Zhu Bin*, Wang Gao-Xue*.Targeting Heat Shock Protein 70 as an antiviral strategy against grass carp reovirus infection. Virus Research. 2018, 247:1-9. (IF="2.736,中科院医学3区)

  (17)Chen Cheng, Shen Yu-Feng, Hu Yang, Liu Lei, Chen Wei-Chao, Wang Gao-Xue*, Zhu Bin*. Highly efficient inhibition of spring viraemia of carp virus replication in vitro mediated by bavachin, a major constituent of Psoralea corlifonia Lynn. Virus Research. 2018. 255:24-35. (IF="2.736,中科院医学3区)

  (18)Zhu Bin*, Zhu Song, Li Jian, Wang Gao-Xue. The developmental toxicity, bioaccumulation and distribution of oxidized single walled carbon nanotubes in Artemia salina. Toxicology Research. 2018. 79:256-264. (IF="1.593,中科院环境科学与生态学3区)

  (19)Zhu Song, Luo Fei, Chen Weichao, Zhu Bin*, Wang Gao-Xue*. Toxicity evaluation of graphene oxide on cysts and three larval stages of Artemia salina. Science of The Total Environment. 2017, 595:101-109. (IF="5.589,Top期刊,中科院环境科学与生态学2区)

  (20)Liu Lei, Hu Yang, Shen Yu-Feng, Wang Gao-Xue*, Zhu Bin*. Evaluation on antiviral activity of coumarin derivatives against spring viraemia of carp virus in epithelioma papulosum cyprini cells. Antiviral Research. 2017, 144:173-185. (IF="4.130,中科院医学2区)

  (21)Hao Kai, Chen Xiao-Hui, Qi Xiao-Zhou, Yu Xiao-Bo, Du En-Qi, Ling Fei, Zhu Bin*, Wang Gao-Xue*. Protective immunity of grass carp induced by DNA vaccine encoding capsid protein gene (vp7) of grass carp reovirus using bacterial ghost as delivery vehicles. Fish & Shellfish Immunology. 2017, 64:414-425. (IF="3.298,Top期刊,中科院农林科学1区)

  (22)Zhang Chen, Zhao Zhao, Zha Ji-Wei, Wang Gao-Xue*, Zhu Bin*. Single-walled carbon nanotubes as delivery vehicles enhance the immunoprotective effect of a DNA vaccine against spring viremia of carp virus in common carp. Fish & Shellfish Immunology. 2017, 71:191-201. (IF="3.298,Top期刊,中科院农林科学1区)

  (23)Liu Lei, Tu Xiao, Shen Yu-Feng, Chen Wei-Chao, Zhu Bin*, Wang Gao-Xue*. The replication of spring viraemia of carp virus can be regulated by reactive oxygen species and NF-κB pathway. Fish & Shellfish Immunology. 2017, 67:211-217. (IF="3.298,Top期刊,中科院农林科学1区)

  (24)Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Mitochondrial impairment and oxidative stress mediated apoptosis induced by α-Fe2O3 nanoparticles in Saccharomyces cerevisiae. Toxicology Research. 2017, 6:719-728. (IF="1.593,中科院环境科学与生态学3区)

  (25)Zhu Song, Luo Fei, Zhu Bin*, Wang Gao-Xue*. Toxicological effects of graphene oxide on Saccharomyces cerevisiae. Toxicology Research. 2017, 6:535-543. (IF="1.593,中科院环境科学与生态学3区)

  (26)Yu Xiao-Bo, Chen Xiao-Hui, Ling Fei, Hao Kai, Wang Gao-Xue*, Zhu Bin*. Moroxydine hydrochloride inhibits grass carp reovirus replication and suppresses apoptosis in Ctenopharyngodon idella kidney cells. Antiviral Research. 2016, 131:156-165. (IF="4.130,中科院医学2区)

  (27)Wang Yuan, Liu Guang-Lu, Li Dong-Liang, Ling Fei, Zhu Bin*, Wang Gao-Xue*. The protective immunity against grass carp reovirus in grass carp induced by a DNA vaccination using single-walled carbon nanotubes as delivery vehicles. Fish & Shellfish Immunology. 2015, 47:732-742. (IF="3.298,Top期刊,中科院农林科学1区)

  (28)Zhu Bin, Liu Guang-Lu, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Development toxicity of functionalized carbon nanotubes on rare minnow embryos and larvae. Nanotoxicology. 2015. 9(5):579-590. (IF="7.913,Top期刊,中科院医学1区)

  (29)Zhu Bin, Liu Guang-Lu, Ling Fei, Wang Gao-Xue*. Carbon nanotube-based nanocarrier loaded with ribavirin against grass carp reovirus. Antiviral Research. 2015, 118:29-38. (IF="4.130,中科院医学2区)

  (30)Zhu Bin, Liu Guang-Lu, Liu Lei, Ling Fei, Wang Gao-Xue*. Assessment of trifloxystrobin uptake kinetics, developmental toxicity and mRNA expression in rare minnow embryos. Chemosphere. 2015, 120:447-455. (IF="5.108,Top期刊,中科院环境科学与生态学2区)

  (31)Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Protective immunity of grass carp immunized with DNA vaccine encoding the vp7 gene of grass carp reovirus using carbon nanotubes as a carrier molecule. Fish & Shellfish Immunology. 2015, 42(2):325-334. (IF="3.298,Top期刊,中科院农林科学1区)

  (32)Zhu Bin, Liu Guang-Lu, Gong Yu-Xin, Ling Fei, Song Lin-Sheng, Wang Gao-Xue*. Single-walled carbon nanotubes as candidate recombinant subunit vaccine carrier for immunization of grass carp against grass carp reovirus. Fish & Shellfish Immunology. 2014, 41(2):279-293. (IF="3.298,Top期刊,中科院农林科学1区)

  (33)Zhu Bin, Gong Yu-Xin, Liu Lei, Li Dong-Liang, Wang Yuan, Ling Fei, Wang Gao-Xue*. Toxic effects of triazophos on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2014, 108:46-54. (IF="5.108,Top期刊,中科院环境科学与生态学2区)

  (34)Zhu Bin, Liu Lei, Li Dong-Liang, Ling Fei, Wang Gao-Xue*. Developmental toxicity in rare minnow (Gobiocypris rarus) embryos exposed to Cu, Zn and Cd. Ecotoxicology and Environmental Safety. 2014, 104:269-277. (IF="4.527,中科院环境科学与生态学3区)

  (35)Zhu Bin, Liu Lei, Gong Yu-Xin, Ling Fei, Wang Gao-Xue*. Triazole-induced toxicity in developing rare minnow (Gobiocypris rarus) embryos. Environmental Science and Pollution Research. 2014, 21(23): 13625-13635. (IF="2.914,中科院环境科学与生态学3区)

  (36)Zhu Bin, Liu Tian-Qiang, Hu Xue-Gang, Wang Gao-Xue*. Developmental toxicity of 3,4-dichloroaniline on rare minnow (Gobiocypris rarus) embryos and larvae. Chemosphere. 2013, 90(3):1132-1139. (IF="5.108,Top期刊,中科院环境科学与生态学2区)

  (37)Zhu Bin, Wu Zong-Fan, Li Jun, Wang Gao-Xue*. Single and joint action toxicity of heavy metals on early developmental stages of Chinese rare minnow (Gobiocypris rarus). Ecotoxicology and Environmental Safety. 2011, 74(8): 2193- 2202. (IF="4.527,中科院环境科学与生态学3区)

  6.3发明专利

  (1)王高学, 朱斌, 刘广路, 凌飞. 碳纳米管载体免注射疫苗、制备方法及其在制备水产免疫苗种中的应用, 2016.01, 中国, 授权号ZL. 201310482649.7.

  (2)王高学, 刘广路, 朱斌, 凌飞. 碳纳米管载抗病毒药物复合物、制备方法及其在水产养殖无病毒携带苗生产中的应用, 2016.01, 中国, 授权号ZL. 201310482759.3.

  7.联系方式

  通讯地址:陕西杨凌西农路22号 西北农林科技大学动物科技学院

  邮编:712100

  Email:zhubin@nwsuaf.edu.cn, zhubin1227@126.com