褚瑰燕
一、基本信息
褚瑰燕,女,1983年7月生,山东泰安人,博士,副教授,博士生导师。2002-2006年本科就读于山东农业大学,2006-2008年硕士就读于中国农业大学,2008-2011年博士就读于日本九州大学。2012年于澳大利亚西澳大学交流访问。2013年进入西北农林科技大学动物科技学院工作。
二、社会兼职
中国畜牧兽医学会养猪学分会理事,中国畜牧兽医学会动物遗传育种学分会会员,中国细胞生物学会会员。《Stem Cell》,《Scientific Report》,《Bioscience Reports》等审稿专家。
三、研究方向
繁殖生理、脂肪沉积对家畜繁殖功能的影响和繁殖营养。
四、开设课程
先后承担《猪生产学》理论和实习课程,参与《猪生产学》课程MOOC化的创新与实践教改项目。
五、学术成果
主持项目:
1. 生物钟基因Bmal1通过Cyp11a1调控母猪卵巢颗粒细胞雌激素合成的分子机制(31802047),国家自然科学基金青年项目,2019-2021,24万元
2. BAMBI高繁殖力转基因猪育种新材料的制备子课题(2016ZX08006-003),国家转基因重大专项,2016-2020, 80万元
3. 种畜禽重要经济性状精准测定技术研发子课题(2017YFD0502002),国家重点研发计划,2017.1-2020.12,43.00万元
4. 仔猪健康养殖关键技术集成与示范(2018ZDXM-NY-035),陕西省重点研发计划,2018-2020,45.00万元
5. Cry1对猪前体脂肪细胞成脂分化的作用及机制研究,博士科研启动费,2015-2017,25万元
6. Leptin在生物钟系统对动物繁殖性能调控中的作用(2015M582717), 中国博士后科学基金(面上项目),2015-2017,5万元
7. BAMBI对猪卵巢颗粒细胞增殖和甾类激素合成的影响及机理研究(2015JQ3073),陕西省自然科学基础研究计划-青年人才项目,2015-2016,3万元
8. Bmal1对猪卵巢颗粒细胞发育调控机制研究(2016BSHEDZZ124),陕西省博士后科研项目, 2016-2017,2万元
9. BAMBI对猪卵巢颗粒细胞发育的影响及机理研究(2452015148),中央高校基本科研业务费,5.5万元2015.9-2015.12
参加项目:
1.猪脂肪沉积关键基因BAMBI的克隆及功能验证(2014ZX0800947B-001),国家转基因重大专项,170.09万,2014.1-2016.12,第3参加人
2.猪肌内脂肪沉积的LncRNA鉴定及其调控机制(31572366),国家自然基金面上项目,76.8万元,第3参与人
主要论著
Chu G, Yoshida K, Narahara S, Uchikawa M, Kawamura M, Yamauchi N, Xi Y, Shigeyoshi Y, Hashimoto S, Hattori MA Alterations of circadian clockworks during differentiation and apoptosis of rat ovarian cells. (Chronobiol Int. 2011,28(6):477-87.)
Chu G, Misawa I, Chen H, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA Contribution of FSH and triiodothyronine to the development of circadian clocks during granulosa cell maturation. (Am J Physiol Endocrinol Metab. 2012, 302(6):E645-653.)
Long Bai, Guiyan Chu*, Yin Mai, Jiameng Zheng, Wusu Wang, Qiangling Zhang, Gongshe Yang Identification and expression analyses of BAMBI mediated by FSH in swine luteinizing granulosa cells. (Theriogenology. 2014, 82:1094-101.)
Wang Wusu,Yin Lin,Bai Long,Ma Guangjun,Zhao Cunzhen,Xiang Aoqi,Pang Weijun,Yang Gongshe,Chu Guiyan Bmal1 interference impairs hormone synthesis and promotes apoptosis in porcine granulosa cells. (Theriogenology. 2017, 99: 63-68.)
Bai Long,Chu Guiyan,Wang Wusu, Xiang Aoqi,Yang Gongshe BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-beta signaling. (Theriogenology. 2017, 100: 24-31.)
Yuan Z, Chu G, Dan Y, Li J, Zhang L, Gao X, Gao H, Li J, Xu S, Liu Z BRCA1: a new candidate gene for bovine mastitis and its association analysis between single nucleotide polymorphisms and milk somatic cell score. (Mol Biol Rep. 2012, 39 (6):6625-31.)
Chen H, Chu G, Zhao L, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112. (Biochem Biophys Res Commun. 2012, 6: 420(2):374-379.)
Liu Z, Chu G Chronobiology in mammalian health. (Mol Biol Rep. 2013, 40(3):2491-2501.)
Chen H, Zhao L, Chu G, Yamauchi N, Shigeyoshi Y, Hashimoto S, Hattori MA FSH induces the development of circadian clockwork in rat granulosa cells via a gap junction protein Cx43-dependent pathway. (American Journal of Physiology- Endocrinology and Metabolism. 2013, 304(6):E566-575.)
Cai R, Sun Y, Qimuge N, Wang G, Wang Y, Chu G, Yu T, Yang G, Pang W. Adiponectin AS lncRNA inhibits adipogenesis by transferring from nucleus to cytoplasm and attenuating Adiponectin mRNA translation. (Biochim Biophys Acta. 2018, 1863(4):420-432.)
Zhao C, Wu H, Qimuge N, Pang W, Li X, Chu G, Yang G. MAT2A promotes porcine adipogenesis by mediating H3K27me3 at Wnt10b locus and repressing Wnt/β-catenin signaling. (Biochim Biophys Acta. 2018, 1863(2):132-142.)
Bai L, Chang HM, Cheng JC, Chu G, Leung PCK, Yang G.ALK2/ALK3-BMPR2/ACVR2A Mediate BMP2-Induced Downregulation of Pentraxin 3 Expression in Human Granulosa-Lutein Cells. (Endocrinology. 2017, 158(10):3501-3511.)
Bai L, Chang HM, Cheng JC, Chu G, Leung PCK, Yang G. Lithium Chloride Increases COX-2 Expression and PGE2 Production in a Human Granulosa-Lutein SVOG Cell Line Via a GSK-3β/β-Catenin Signaling Pathway. (Endocrinology. 2017, 158(9):2813-2825.)
Bai L, Chang HM, Cheng JC, Chu G, Leung PCK, Yang G. Lithium chloride inhibits StAR and progesterone production through GSK-3β and ERK1/2 signaling pathways in human granulosa-lutein cells.(Mol Cel Endocrinol. 2018,461:89-99.)
Bai L, Chang HM, Cheng JC, Klausen C, Chu G, Leung PCK, Yang G. SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells. (Cell Signal. 2017,37:52-61.)
Mai Y, Zhang Z, Yang H, Dong P, Chu G, Yang G, Sun S. BMP and activin membrane-bound inhibitor (BAMBI) inhibits the adipogenesis of porcine preadipocytes through Wnt/β-catenin signaling pathway. (Biochem Cell Biol. 2014, 92(3):172-182.)
Hattori M-A, Chu G, Yoshida K, Uchikawa M, Narahara S, Hirata M, He PJ, Yamauchi N Circadian pacemaker in ovary and uterus during differentiation and apoptosis. In “Circadian Rhythms: Biology, Cognition and Disorders”, NOVA publishers, New York, ISBN: 978-1-61324-858-4, PP. 209-245, 2012.03.
奶牛分子育种技术研究。中国农业大学出版社,2012 年。
六、获奖情况:
1. 2016年,杨凌示范区科学技术奖一等奖
2. 2011年,日本学术振兴学会青年学者海外交流政府资助
3. 2011年,北京市科学技术奖:中国荷斯坦牛分子育种关键技术研究与应用
4. 2008.10 ~ 2011.09 日本政府文部省奖学金
七、联系方式
通讯地址:陕西省咸阳市杨凌区西农路22号西北农林科技大学动物科技学院419室
邮编:712100
联系电话(微信):15829268197
Email:guiyanchu@nwafu.edu.cn
QQ:185260147